Publications
On this page you can find all published peer-reviewed publications related to the NAPKON project. For more information or if your publication is not listed don’t hesitate to contact info@napkon.de.
Pulmonary vascular remodeling in Fra-2 transgenic mice is driven by type 2 inflammation and accompanied by pulmonary vascular hyperresponsiveness
Birnhuber A, Biasin V, Jain PP, Kwiatkowski G, Boiarina E, Wilhelm J, Ahrens K, Nagaraj C, Olschewski A, Witzenrath M, Chlopicki S, Marsh LM, Tabeling C, Kwapiszewska G
Am J Physiol Lung Cell Mol Physiol.; 2025 Mar 1;328(3):L413-L429. DOI
Genome-wide association study of post COVID-19 syndrome in a population-based cohort in Germany
Ruß AK, Schreiber S, Lieb W, Vehreschild JJ, Heuschmann PU, Illig T, Appel KS, Vehreschild MJGT, Krefting D, Reinke L, Viebke A, Poick S, Störk S, Reese JP, Zoller T, Krist L, Ellinghaus D, Foesel BU, Gieger C, Lorenz-Depiereux B, Witzenrath M, Anton G, Krawczak M, Heyckendorf J, Bahmer T
Sci Rep.; 2025 May 6;15(1):15791. DOI PMID: 40328884; PMCID: PMC12056214
Managing withdrawals and exclusions of study participants in COVID-19-research by NUKLEUS
Valentin H, Rau H, Fiedler-Lacombe L, Blumentritt A, Heim E, Rudolph A, Leyh K, Kraus M, Lorenz-Depiereux B, Chaplinskaya I, Schäfer C, Schaller J, Vehreschild JJ, Stecher M, Scherer M, Witzenrath M, Balzuweit B, Schreiber S, Bahmer T, Lieb W, Cordes S, Hoffmann W, Hanß S, Stahl D
BMC Med Res Methodol.; 2025 May 29;25(1):148. DOI
Predicting the risk of intensive care unit admission in patients with COVID-19 presenting in the emergency room: Development and evaluation of the CROSS score
Xiang W, Steinbeis F, Dhindsa K, Kurth F, Lingscheid T, Thibeault C, Meyer HJ, Suttorp N, Mittermaier M, Stecher M, Scherer M, Hagen M, Mitrov L, Geisler R, Appel KS, Hopff SM, Koll C, Nunes de Miranda SM, Weismantel C, Reese JP, Heuschmann P, Miljukov O, Nürnberger C, Sander LE, Vehreschild JJ, Witzenrath M, van Smeden M, Zoller T
Clin Infect Dis.; 2025 Jun 4;80(5):1022-1031. DOI
Endothelin-1 in combination with CRB-65 enhance risk stratification in COVID-19 patients. Infection
Farhat I, Rosolowski M, Ahrens K, Lienau J, Ahnert P, Pletz M, Rohde G, Rupp J, Witzenrath M, Scholz M; CAPNETZ Study Group; PROGRESS Study Group
Infection.; 2025 Aug 19. DOI
Subdomains of Post-COVID Syndrome (PCS) – a population-based study
Ballhausen-Lübcker S, Ruß AK, Lieb W, Schäfer A, Krist L, Fricke J, Scheibenbogen C, Rabe KF, Maetzler W, Maetzler C, Laudien M, Frank D, Heyckendorf J, Miljukov O, Haeusler KG, El Mokhtari NE, Witzenrath M, Vehreschild JJ, Appel KS, Chaplinskaya-Sobol I, Tamminga T, Nürnberger C, Schmidbauer L, Morbach C, Störk S, Reese JP, Keil T, Heuschmann P, Schreiber S, Krawczak M, Bahmer T
BMC Infect Dis.; 2025 Aug 26;25(1):1072. DOI
Soluble ACE2 correlates with severe COVID-19 and can impair antibody responses
Lebedin M, Ratswohl C, Garg A, Schips M, García CV, Spatt L, Thibeault C, Obermayer B, Weiner J, Velásquez IM, Gerhard C, Stubbemann P, Hanitsch LG, Pischon T, Witzenrath M, Sander LE, Kurth F, Meyer-Hermann M, de la Rosa K
iScience.,24;27(3):109330. DOI
Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to M. tuberculosis infection
Nieuwenhuizen NE, Nouailles G, Sutherland JS, Zyla J, Pasternack AH, Heyckendorf J, Frye BC, Höhne K, Zedler U, Bandermann S, Abu Abed U, Brinkmann V, Gutbier B, Witzenrath M, Suttorp N, Zissel G, Lange C, Ritvos O, Kaufmann SHE,
mBio, 2024; 15:e03408-23
Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV-2 variants delta and omicron-results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP)
Hopff SM, Appel KS, Miljukov O, Schneider J, Addo MM, Bals R, Bercker S, Blaschke S, Bröhl I, Büchner N, Dashti H, Erber J, Friedrichs A, Geisler R, Göpel S, Hagen M, Hanses F, Jensen BO, Keul M, Krawczyk A, Lorenz-Depiereux B, Meybohm P, Milovanovic M, Mitrov L, Nürnberger C, Obst W, Römmele C, Schäfer C, Scheer C, Scherer M, Schmidt J, Seibel K, Sikdar S, Tebbe JJ, Tepasse PR, Thelen P, Vehreschild MJGT, Weismantel C, Vehreschild JJ
Infection., 2024 May 3. DOI
Development of a long noncoding RNA-based machine learning model to predict COVID-19 in-hospital mortality
Devaux Y, Zhang L, Lumley AI, Karaduzovic-Hadziabdic K, Mooser V, Rousseau S, Shoaib M, Satagopam V, Adilovic M, Srivastava PK, Emanueli C, Martelli F, Greco S, Badimon L, Padro T, Lustrek M, Scholz M, Rosolowski M, Jordan M, Brandenburger T, Benczik B, Agg B, Ferdinandy P, Vehreschild JJ, Lorenz-Depiereux B, Dörr M, Witzke O, Sanchez G, Kul S, Baker AH, Fagherazzi G, Ollert M, Wereski R, Mills NL, Firat H
Nat Commun., 2024 May 20; 15(1):4259
Creation of Standardized Common Data Elements for Diagnostic Tests in Infectious Disease Studies: Semantic and Syntactic Mapping
Stellmach C, Hopff SM, Jaenisch T, Nunes de Miranda SM, Rinaldi E; NAPKON, LEOSS, ORCHESTRA, and ReCoDID Working Groups
J Med Internet Res.; 2024 Jun 10;26:e50049. DOI
A precise performance-based reimbursement model for the multi-centre NAPKON cohorts – development and evaluation
Appel KS, Lee CH, Nunes de Miranda SM, Maier D, Reese JP, Anton G, Bahmer T, Ballhausen S, Balzuweit B, Bellinghausen C, Blumentritt A, Brechtel M, Chaplinskaya-Sobol I, Erber J, Fiedler K, Geisler R, Heyder R, Illig T, Kohls M, Kollek J, Krist L, Lorbeer R, Miljukov O, Mitrov L, Nürnberger C, Pape C, Pley C, Schäfer C, Schaller J, Schattschneider M, Scherer M, Schulze N, Stahl D, Stubbe HC, Tamminga T, Tebbe JJ, Vehreschild MJGT, Wiedmann S, Vehreschild JJ
Sci Rep.; 2024 Jun 13;14(1):13607. DOI PMID: 38871878; PMCID: PMC11176345
Definition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON)
Appel KS, Nürnberger C, Bahmer T, Förster C, Polidori MC, Kohls M, Kraus T, Hettich-Damm N, Petersen J, Blaschke S, Bröhl I, Butzmann J, Dashti H, Deckert J, Dreher M, Fiedler K, Finke C, Geisler R, Hanses F, Hopff SM, Jensen BO, Konik M, Lehnert K, de Miranda SMN, Mitrov L, Miljukov O, Reese JP, Rohde G, Scherer M, Tausche K, Tebbe JJ, Vehreschild JJ, Voit F, Wagner P, Weigl M, Lemhöfer C; NAPKON Study Group (2024)
Infection; DOI
Depression and fatigue six months post-COVID-19 disease are associated with overlapping symptom constellations: A prospective, multi-center, population-based cohort study
Weiß M, Gutzeit J, Appel KS, Bahmer T, Beutel M, Deckert J, Fricke J, Hanß S, Hettich-Damm N, Heuschmann PU, Horn A, Jauch-Chara K, Kohls M, Krist L, Lorenz-Depiereux B, Otte C, Pape D, Reese JP, Schreiber S, Störk S, Vehreschild JJ, Hein G; NAPKON Study Group (2024)
J Affect Disord; DOI
Predictors of non-recovery from fatigue and cognitive deficits after COVID-19: a prospective, longitudinal, population-based study
Hartung TJ, Bahmer T, Chaplinskaya-Sobol I, Deckert J, Endres M, Franzpötter K, Geritz J, Haeusler KG, Hein G, Heuschmann PU, Hopff SM, Horn A, Keil T, Krawczak M, Krist L, Lieb W, Maetzler C, Montellano FA, Morbach C, Neumann C, Nürnberger C, Russ AK, Schmidbauer L, Schmidt S, Schreiber S, Steigerwald F, Störk S, Zoller T, Maetzler W, Finke C; NAPKON Study Group (2024)
EClinicalMedicine; DOI
Integration von Bestandsdaten aus Kohorten- und Registerstudien in ein existierendes Forschungsnetzwerk: Nationales Pandemie Kohorten Netz (NAPKON) [Integration of Inventory Data from Cohort and Registry Studies into an Existing Research Network: National Pandemic Cohort Network (NAPKON)]
Hofmann AL, Vehreschild JJ, Witzenrath M, Hoffmann W, Illig T, Schreiber S, Anton G, Hellmuth JC, Muenchhoff M, Scherer C, Pley C, Thibeault C, Kurth F, Berger S, Hummel M, Hopff SM, Stecher M, Appel K, Stahl D, Kraus M, Lorenz-Depiereux B, Hanß S, von Kielmansegg S, Schlünder I, Niemeyer A, Heuschmann P, Krawczak M, Reese JP
Gesundheitswesen. 2024 Oct;86(10):647-654. German. DOI Epub; 2024 Aug 22; PMID: 39173676; PMCID: PMC11469301
The life-saving benefit of dexamethasone in severe COVID-19 is linked to a reversal of monocyte dysregulation
Cell.; 2024 Aug 8;187(16):4318-4335.e20. DOI Epub 2024 Jul 3. PMID: 38964327
A new phenotype of patients with post-COVID-19 condition is characterised by a pattern of complex ventilatory dysfunction, neuromuscular disturbance and fatigue symptoms
Steinbeis F, Kedor C, Meyer HJ, Thibeault C, Mittermaier M, Knape P, Ahrens K, Rotter G, Temmesfeld-Wollbrück B, Sander LE, Kurth F, Witzenrath M, Scheibenbogen C, Zoller T
ERJ Open Res.; 2024 Oct 7;10(5):01027-2023. DOI PMID: 39377086; PMCID: PMC11456967
Analysis of acute COVID-19 including chronic morbidity: protocol for the deep phenotyping National Pandemic Cohort Network in Germany (NAPKON-HAP)
Steinbeis F, Thibeault C, Steinbrecher S, Ahlgrimm Y, Haack IA, August D, Balzuweit B, Bellinghausen C, Berger S, Chaplinskaya-Sobol I, Cornely O, Doeblin P, Endres M, Fink C, Finke C, Frank S, Hanß S, Hartung T, Hellmuth JC, Herold S, Heuschmann P, Heyckendorf J, Heyder R, Hippenstiel S, Hoffmann W, Kelle SU, Knape P, Koehler P, Kretzler L, Leistner DM, Lienau J, Lorbeer R, Lorenz-Depiereux B, Lüttke CD, Mai K, Merle U, Meyer-Arndt LA, Miljukov O, Muenchhoff M, Müller-Plathe M, Neuhann J, Neuhauser H, Nieters A, Otte C, Pape D, Pinto RM, Pley C, Pudszuhn A, Reuken P, Rieg S, Ritter P, Rohde G, Rönnefarth M, Ruzicka M, Schaller J, Schmidt A, Schmidt S, Schwachmeyer V, Schwanitz G, Seeger W, Stahl D, Stobäus N, Stubbe HC, Suttorp N, Temmesfeld B, Thun S, Triller P, Trinkmann F, Vadasz I, Valentin H, Vehreschild M, von Kalle C, von Lilienfeld-Toal M, Weber J, Welte T, Wildberg C, Wizimirski R, Zvork S, Sander LE, Vehreschild J, Zoller T, Kurth F, Witzenrath M
Infection.; 2024 Feb;52(1):93-104. DOI Epub 2023 Jul 11; PMID: 37434025; PMCID: PMC10811153
Biomarkers troponin and procalcitonin in addition to CRB-65 enhance risk stratification in patients with community-acquired pneumonia
Farhat I, Rosolowski M, Ahrens K, Lienau J, Ahnert P, Pletz M, Rohde G, Rupp J, Scholz M, Witzenrath M; CAPNETZ Study Group
ERJ Open Res.; 2024 Dec 2;10(6):00420-2024. DOI
Analysis of acute COVID‑19 including chronic morbidity: protocol for the deep phenotyping National Pandemic Cohort Network in Germany (NAPKON‑HAP)
Steinbeis F, Thibeault C, Steinbrecher S, Ahlgrimm Y, an Haack I, August D, Balzuweit B, Bellinghausen C, Berger S, Chaplinskaya‑Sobol I, Cornely O, Doeblin P, Endres M, Fink C, Finke C, Frank S, Hanß S, Hartung T, Hellmuth JC, Herold S, Heuschmann P, Heyckendorf J, Heyder R, Hippenstiel S, Hoffmann W, Kelle SU, Knape P, Koehler P, Kretzler L, Leistner DM, Lienau J, Lorbeer R, Lorenz‑Depiereux B, Lüttke CD, Mai K, Merle U, Meyer‑Arndt LA, Miljukov O, Muenchhoff M, Müller‑Plathe M, Neuhann J, Neuhauser H, Nieters A, Otte C, Pape D, Pinto RM, Pley C, Pudszuhn A, Reuken P, Rieg S, Ritter P, Rohde G, Rönnefarth M, Ruzicka M, Schaller J, Schmidt A, Schmidt S, Schwachmeyer V, Schwanitz G, Seeger W, Stahl D, Stobäus N, Stubbe HC, Suttorp N, Temmesfeld B, Thun S, Triller P, Trinkmann F, Vadasz I, Valentin H, Vehreschild M, von Kalle C, von Lilienfeld‑Toal M, Weber J, Welte T, Wildberg C, Wizimirski R, Zvork S, Sander LE, Vehreschild J, Zoller T, Kurth F, Witzenrath M
Infection, 2024, 52, 93-104. DOI
Appel KS, Nürnberger C, Bahmer T, Förster C, Polidori MC, Kohls M, Kraus T, Hettich-Damm N, Petersen J, Blaschke S, Bröhl I, Butzmann J, Dashti H, Deckert J, Dreher M, Fiedler K, Finke C, Geisler R, Hanses F, Hopff SM, Jensen BO, Konik M, Lehnert K, Miranda SMN, Mitrov L, Miljukov O, Reese J, Rohde G, Scherer M, Tausche K, Tebbe JJ, Vehreschild JJ, Voit F, Wagner P, Weigl M, Lemhöfer C, Alsaad K, Hamelmann E, Heidenreich H, Hornberg C, Kulamadayil-Heidenreich NSA, Maasjosthusmann P, Muna A, Ruwe M, Stellbrink C, Buechner N, Dashti Y, Tessmer C, Laumerich B, Silberbaur I, Bader S, Engelmann M, Fuchs A, LangerA, Maerkl B, Messmann H, Muzalyova A, Roemmele C, Altmann H, Berner R, Dressen S, Koch T, Lindemann D, Seele K, Spieth P, Toepfner N, Bonin SV, Feldt T, Keitel V, Killer A, Knopp L, Luedde T, Lutterbeck M, Paluschinski M, Pereira JPV, Timm J, Kraska D, Kremer AE, Leppkes M, Mang J, Neurath MF, Prokosch HU, Schmid J, Vetter M, Willam C, Wolf K, Arendt C, Bellinghausen C, Cremer S, Groh A, Gruenewaldt A, Khodamoradi Y, Klinsing S, Vehreschild M, Vogl T, Addo M, Almahfoud M, Engels ALF, Jarczak D, Kerinn M, Kluge S, Kobbe R, Petereit S, Schlesner C, Zeller T, Baber R, Bercker S, Krug N, Mueller SD, Wirtz H, Boeckel G, Meier JA, Nowacki T, Tepasse PR, Vollenberg R, Wilms C, Dahl E, Marx N, Mueller-Wieland D, Wipperfuerth J, Brochhausen-Delius C, Burkhardt R, Feustel M, Haag O, Hansch S, Malfertheiner M, Niedermair T, Schuster P, Wallner S, Barkey W, Erber J, Fricke L, Lieb J, Michler T, Mueller L, Spinner C, Winter C, Bitzer M, Bunk S, Göpel S, Haeberle H, Kienzle K, Mahrhofer H, Malek N, Rosenberger P, Struemper C, Trauner F, Frantz S, Frey A, Haas K, Haertel C, Herrmann J, Isberner N, Liese J, Meybohm P, Schmidt J, Schulze P, Brinkmann F, Brueggemann Y, Gambichler T, Hellwig K, Luecke T, Reinacher-Schick A, Schmidt WE, Schuette C, Steinmann E, Torres Reyes C, Hafke A, Hermanns G, Nussbeck SY, Santibanez-Santana M, Zeh S, Brochhagen L, Dolff S, Elsner C, Krawczyk A, Madel RJ, Otte M, Witzke O, Becker K, Doerr M, Piasta N, Schaefer E, Scheer C, Arlt A, Griesinger F, Guenther U, Hamprecht A, Juergens K, Kluge A, Meinhardt C, Meinhardt K, Petersmann A, Prenzel R, Brechtel M, Laugwitz M, Lee C, Sauer G, Schulze N, Seibel K, Stecher M, Hagen M, Sikdar S, Weismantel C, Wolf L, Günther K, Haug J, Haug F, Fiessler C, Heuschmann PU, Schmidbauer L, Jiru-Hillmann S, Bahls T, Valentin H, Chaplinskaya I, Hanß S, Krefting D, Pape C, Rainers M, Schoneberg A, Weinert N, Kraus M, Lorenz-Depiereux B, Lorbeer R, Schaller J, Fricke J, Krist L, Rönnefarth M, Schmidt S, Bahmer T, Hermes A, Krawczak M, Lieb W, Tamminga T, Herold S, Heuschmann P, Heyder R, Illig T, Witzenrath M, the NAPKON Study Group
Infection, 2024, xx, xxxx. DOI
Journal of Affective Disorders, 2024, 352, 296-305. DOI
Impact of Clinical Study Implementation on Data Quality Assessments – Using Contradictions within Interdependent Health Data Items as a Pilot Indicator
Yusuf KO, Chaplinskaya-Sobol I, Schoneberg A, Hanss S, Valentin H, Lorenz-Depiereux B, Hansch S, Fiedler K, Scherer M, Sikdar S, Miljukov O, Reese J-P, Wagner P, Bröhl I, Geisler R, Vehreschild JJ, Blaschke S, Bellinghausen C, Milovanovic M, Krefting D.
German Medical Data Sciences – Science close to People, 2023, 307, 152-158 DOI
Interoperable, Domain-Specific Extensions for the German Corona Consensus (GECCO) COVID-19 Research Data Set Using an Interdisciplinary, Consensus-Based Workflow: Data Set Development Study
Lichtner G, Haese T, Brose S, Röhrig L, Lysyakova L, Rudolph S, Uebe M, Sass J, Bartschke A, Hillus D, Kurth F, Sander L, Eckart F, Toepfner N, Berner R, Frey A, Dörr M, Vehreschild J, von Kalle C, Thun S.
JMIR Med Inform 2023;11:e45496 DOI
Impact of Coronavirus Disease 2019 on Hospital Admissions, Health Status, and Behavioral Changes of Patients with COPD.
Pappe E, Hammerich R, Saccomanno J, Sgarbossa T, Pohrt A, Schmidt B, Grah C, Eisenmann S, Holland A, Eggeling S, Stanzel F, Witzenrath M, Hübner RH.
Chronic Obstr Pulm Dis. 2023 Jul 26;10(3):211-223 DOI
Increased circulating fibronectin, depletion of natural IgM and heightened EBV, HSV-1 reactivation in ME/CFS and long COVID
Liu Z, Hollmann C, Kalanidhi S, Grothey A, Keating S, Mena-Palomo I, Lamer S, Schlosser A, Kaiping A, Scheller C, Sotzny F, Horn A, Nürnberger C, Cejka V, Afshar B, Bahmer T, Schreiber S, Vehreschild JJ, Miljukov O, Schäfer C, Kretzler L, Keil T, Reese JP, Eichner FA, Schmidbauer L, Heuschmann PU, Störk S, Morbach C, Riemekasten G, Beyersdorf N, Scheibenbogen C, Naviaux RK, Williams M, Ariza ME, Prusty BK.
medRxiv. 2023 DOI
A Systematic Review of Predictor Composition, Outcomes, Risk of Bias, and Validation of Coronavirus Disease 2019 (COVID-19) Prognostic Scores
Clinical Infectious Diseases. 2023 Oct25:ciad618 DOI
Ethical and coordinative challenges in setting up a national cohort study during the COVID-19 pandemic in Germany
Tilch K, Hopff SM, Appel K, Kraus M, Lorenz‑Depiereux B, Pilgram L, Anton G, Berger S, Geisler R, Haas K, Illig T, Krefting D, Lorbeer R, Mitrov L, Muenchhoff M, Nauck M, Pley C, Reese J-P, Rieg S, Scherer M, Stecher M, Stellbrink C, Valentin H, Winter C, Witzenrath M, Vehreschild, JJ.
BMC Medical Ethics. 2023, 24(28) DOI.
Thibeault C, Bardtke L, Vanshylla K, di Cristanziano V, Eberhardt KA, Stubbemann P, Hillus D, Tober-Lau P, Mukherjee P, Münn F, Lippert LJ, Helbig ET, Lingscheid T, Steinbeis F, Mittermaier M, Witzenrath M, Zoller T; Pa-COVID study group; Klein F, Sander LE, Kurth F.
JCI Insight. 2023, 8(8):e166711. DOI
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The Development of Interoperable, Domain-Specific Extensions for the German Corona Consensus (GECCO) COVID-19 Research Dataset Using an Interdisciplinary, Consensus-Based Workflow: Dataset Development Study
Lichtner G, Haese T, Brose S, Röhrig L, Lysyakova L, Rudolph S, Uebe M, Sass J, Bartschke A, Hillus D, Kurth F, Sander LE, Eckart F, Toepfner N, Berner R, Frey A, Dörr M, Vehreschild JJ, von Kalle C, Thun S
JMIR Med Inform, 2023, 18;11:e45496. DOI
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Discriminating promiscuous from target-specific autoantibodies in COVID-19
Lebedin M, García CV, Spatt L, Ratswohl C, Thibeault C, Ostendorf L, Alexander T, Paul F, Sander LE, Kurth F, de la Rosa K.
Eur J Immunol. 2023, 53(5):e2250210. DOI
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Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: an analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort
Shi Y, Strobl R, Apfelbacher C, Bahmer T, Geisler R, Heuschmann P, Horn A, Hoven H, Keil T, Krawczak M, Krist L, Lemhöfer C, Lieb W, Lorenz-Depiereux B, Mikolajczyk R, Montellano FA, Reese J-P, Schreiber S, Skoetz N, Störk S, Vehreschild JJ, Witzenrath M, Grill E, on behalf of the NAPKON Study Group
Infection 2023, 51, 1679–1694. DOI
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Consistency as a Data Quality Measure for German Corona Consensus Items Mapped from National Pandemic Cohort Network Data Collections
Yusuf KO, Miljukov O, Schoneberg A , Hanß S, Wiesenfeldt M, Stecher M, Mitrov L, Hopff SM, Steinbrecher S, Kurth F, Bahmer T, Schreiber S, Pape D, Hofmann A-L, Kohls M, Störk S, Stubbe HC, Tebbe JJ, Hellmuth JC, Erber J, Krist L, Rieg S, Pilgram L, Vehreschild JJ, Reese J-P, Krefting D.
Methods of Infection in Medicine 2023, 62(S 01): e47-e56. DOI
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Persisting chemosensory dysfunction in COVID-19 – a cross-sectional population-based survey.
Winkelmann S, Korth A, Voss B, Nasr MA, Behrend N, Pudszuhn A, Hofmann VM, Schendzielorz C, Maetzler C, Hermes A, Borzikowsky C, Bahmer T, Lieb W, Schreiber S, Störk S, Montellano FA, Witzenrath M, Keil T, Krawczak M, Laudien M, on behalf of the NAPKON study group.
Rhinology 2023, 61-1, 12-23. DOI.
Early and Rapid Identification of COVID-19 Patients with Neutralizing Type I Interferon Auto-antibodies.
Akbil B, Meyer T, Stubbemann P, Thibeault C, Staudacher O, Niemeyer D, Jansen J, Mühlemann B, Doehn J, Tabeling C, Nusshag C, Hirzel C, Sanchez DS, Nieters A, Lother A, Duerschmied D, Schallner N, Lieberum JN, August D, Rieg S, Falcone V, Hengel H, Kölsch U, Unterwalder N, Hübner RH, Jones TC, Suttorp N, Drosten C, Warnatz K, Spinetti T, Schefold JC, Dörner T, Sander LE, Corman VM, Merle U, Kurth F, von Bernuth H, Meisel C, Goffinet C.
Journal of Clinical Immunology 2022, 42(6), 1111-29. DOI
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Severity, predictors and clinical correlates of Post-COVID syndrome (PCS) in Germany: A prospective, multi-centre, population-based cohort study.
Bahmer TJ, Borzikowsky C, Lieb W, Horn A, Krist L, Fricke J, Scheibenbogen C, Rabe K F, Maetzler C, Laudien M, Frank D, Ballhausen S, Hermes A, Miljukov O, Haeusler KG, Eddine El Mokhtari N, Witzenrath M, Vehreschild JJ, Krefting D, Pape D, Montellano FA, Kohls M, Morbach C, Störk S, Reese JP, Keil T, Heuschmann P, Krawczak M, Schreiber S. on behalf of the NAPKON study group.
eClinicalMedicine 2022, 51, 101549. DOI
Kewords: #postcovid
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Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.
Dannebaum R, Suwalski P, Asgharian H, Du Zhipei G, Lin H, Weiner J, Holtgrewe M, Thibeault C, Müller M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Blüher A, Siemann S, Telman D, Suttorp N, Witzenrath M, Hippenstiel S, Skurk C, Poller W, Sander LE, Beule D, Kurth F, Guettouche T, Landmesser U, Berka J, Luong K. Pa-COVID Study Group, Rubelt F, Heidecker B.
eClinicalMedicine 2022, 48, 101438. DOI
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Fatigue and cognitive impairment after COVID-19: A prospective multicentre study
Hartung TJ, Neumann, C, Bahmer T, Chaplinskaya-Sobol I, Endres M, Geritz J, Haeusler K G, Heuschmann P, Hildesheim H, Hinz A, Hopff S, Horn A, Krawczak M, Krist L, Kudelka J, Lieb W, Maetzler C, Mehnert-Theuerkauf A, Montellano F A, Morbach C, Schmidt S, Schreiber S, Steigerwald F, Störk S, Maetzler W.
eClinicalMedicine 2022, 53, 101651. DOI
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Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.
Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC.
European Respiratory Journal 2022, 60(6), 2102725. DOI
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Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients.
Jakob CEM, Hopff SM, Meurers T, Huang Lee C, Kohls M, Stellbrink C, Thibeault C, Reinke L, Steinbrecher S, Schreiber S, Mitrov L, Frank S, Miljukov O, Erber J, Hellmuth JC, Reese JP, Steinbeis F, Bahmer T, Hagen M, Meybohm P, Hansch S, Vadász I, Krist L, Jiru-Hillmann S, Prasser F, Vehreschild JJ on behalf of the NAPKON study group.
Nature Scientific Data 2022, 9, 776. DOI
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Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia.
Kühnapfel A, Horn K, Klotz U, Kiehntopf M, Rosolowski M, Loeffler M, Ahnert P, Suttorp N, Witzenrath M, Scholz M.
Genes (Basel) 2022, 13(1), 111. DOI
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Post COVID – Just a Matter of defintion?
Lemhöfer C, Appel KS, Häuser W, Hettich N, Kohls M, Polidori MC
Deutsche Medizinische Wochenschrift 2022, 147(21), 1391-1397. DOI
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Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study.
Lingscheid T, Lippert LJ, Hillus D, Kruis T, Thibeault C, Helbig ET, Tober-Lau P, Pfäfflin F, Müller-Redetzky H, Witzenrath M, Zoller T, Uhrig A, Opitz B, Suttorp N, Kramer TS, Sander LE, Stegemann MS, Kurth F.
Infection 2022, 50(6), 1441-1452. DOI
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Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study.
Mühlemann B, Thibeault C, Hillus D, Helbig ET, Lippert LJ, Tober-Lau P, Schwarz T, Müller MA, Witzenrath M, Suttorp N, Sander LE, Drosten C, Jones TC, Corman VM, Kurth F.
Clinical Microbiology and Infectection 2021, 27(10), 1520 e7- e10. DOI
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The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics.
Schons M, Pilgram L, Reese JP, Stecher M, Anton G, Appel KS, Bahmer T, Bartschke A, Bellinghausen C, Bernemann I, Brechtel M, Brinkmann F, Brünn C, Dhillon C, Fiessler C, Geisler R, Hamelmann E, Hansch S, Hanses F, Hanß S, Herold S, Heyder R, Hofmann A-L, Hopff SM, Horn A, Jakob C, Jiru-Hillmann S, Keil T, Khodamoradi Y, Kohls M, Kraus M, Krefting D, Kunze S, Kurth F, Lieb W, Lippert LJ, Lorbeer R, Lorenz-Depiereux B, Maetzler C, Miljukov O, Nauck M, Pape D, Püntmann V, Reinke L, Römmele C, Rudolph S, Sass J, Schäfer C, Schaller J, Schattschneider M, Scheer C, Scherer M, Schmidt S, Schmidt J, Seibel K, Stahl D, Steinbeis F, Störk S, Tauchert M, Tebbe JJ, Thibeault C, Toepfner N, Ungethüm K, Vadasz I, Valentin H, Wiedmann S, Zoller T, Nagel E, Krawczak M, von Kalle C, Illig T, Schreiber S, Witzenrath M, Heuschmann P, Vehreschild JJ & NAPKON Research Group.
European Journal of Epidemiology 2022, 37(8), 849-870 DOI
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Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescents.
Steinbeis F, Knape P, Mittermaier M, Helbig ET, Tober-Lau P, Thibeault C, Lippert LJ, Xiang W, Müller-Plathe M, Steinbrecher S, Meyer HJ, Ring RM, Ruwwe-Glösenkamp C, Alius F, Li Y, Müller-Redetzky H, Uhrig A, Lingscheid T, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Witzenrath M, Zoller T.
Respiratory Medidicine 2022, 202, 106968. DOI
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A multiplex protein panel assay for severity prediction and outcome prognosis in patients with COVID-19: An observational multi-cohort study.
Wang Z, Cryar A, Lemke O, Tober-Lau P, Ludwig D, Helbig ET, Hippenstiel S, Sander L-E, Blake D, Lane CS, Sayers RL, Mueller C, Zeiser J, Townsend StJ, Demichev V, Mülleder M, Kurth F, Sirka E, Hartl J, Ralser M.
eClinicalMedicine 2022, 49, 101495. DOI
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Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single cell transcriptomics.
Wyler E, Adler JM, Eschke K, Alves GT, Peidli S, Pott F, Kazmierski J, Michalick L, Kershaw O, Bushe J, Andreotti S, Pennitz P, Abdelgawad A, Postmus D, Goffinet C, Kreye J, Reincke SM, Prüss H, Blüthgen N, Gruber AD, Kuebler WM, Witzenrath M, Landthaler M, Nouailles G, Trimpert J.
Molecular Therapy 2022, 30(5), 1952-1965. DOI
A time-resolved proteomic and prognostic map of COVID-19.
Demichev V, Tober-Lau P, Lemke O, Nazarenko T, Thibeault C, Whitwell H, Röhl A, Freiwald A, Szyrwiel L, Ludwig D, Correia-Melo C, Aulakh SK, Helbig ET, Stubbemann P, Lippert LJ, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Mittermaier M, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Enghard P, Zelezniak A, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Müller-Redetzky H, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE, PA-COVID-19 Study group, Ralser M, Kurth F.
Cell Systems 2021, 12(8), 780-794.e7. DOI
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CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity.
Doehn JM, Tabeling C, Biesen R, Saccomanno J, Madlung E, Pappe E, Gabriel F, Kurth F, Meisel C, Corman VM, Hanitsch LG, Treskatsch S, Heim K, Stegemann MS, Ruwwe-Glösenkamp C, Müller-Redetzky HC, Uhrig A, Somasundaram R, Spies C, von Bernuth H, Hofmann J, Drosten C, Suttorp N, Witzenrath M, Sander LE, Hübner RH.
Infection 2021, 49(4), 757-762. DOI
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Heart failure with preserved ejection fraction according to the HFA-PEFF score in COVID-19 patients: clinical correlates and echocardiographic findings.
Hadzibegovic S, Lena A, Churchill TW, Ho JE, Potthoff S, Denecke C, Rösnick L, Heim KM, Kleinschmidt M, Sander LE, Witzenrath M, Suttorp N, Krannich A, Porthun J, Friede T, Butler J, Wilkenshoff U, Pieske B, Landmesser U, Anker SD, Lewis GD, Tschöpe C, Anker MS.
European Journal of Heart Failure 2021, 23(11), 1891-1902. DOI
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Long-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP).
Horn A, Krist L, Lieb W, Montellano FA, Kohls M, Haas K, Gelbrich G, Bolay-Gehrig SJ, Morbach C, Reese JP, Störk S, Fricke J, Zoller T, Schmidt S, Triller P, Kretzler L, Rönnefarth M, Von Kalle C, Willich SN, Kurth F, Steinbeis F, Witzenrath M, Bahmer T, Hermes A, Krawczak M, Reinke L, Maetzler C, Franzenburg J, Enderle J, Flinspach A, Vehreschild J, Schons M, Illig T, Anton G, Ungethüm K, Finkenberg BC, Gehrig MT, Savaskan N, Heuschmann PU, Keil T, Schreiber, S.
Infection 2021, 49(6), 1277–1287. DOI
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Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure.
Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Müller-Redetzky H, Suttorp N, Kutz F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM.
European Respiratory Journal 2021, 57(3), 2002384. DOI
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Impact of dexamethasone on SARS-CoV-2 concentration kinetics and antibody response in hospitalized COVID-19 patients: results from a prospective observational study.
Mühlemann B, Thibeault C, Hillus D, Helbig ET, Lippert LJ, Tober-Lau P, Schwarz T, Müller MA; Pa-COVID-19 collaborative study group, Witzenrath M, Suttorp N, Sander LE, Drosten C, Jones TC, Corman VM, Kurth F.
Clinical Microbiology and Infection 2021, 27(10), 1520.e7-1520.e10. DOI
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Disease Severity, Fever, Age, and Sex Correlate With SARS-CoV-2 Neutralizing Antibody Responses.
Schlickeiser S, Schwarz T, Steiner S, Wittke K, Al Besher N, Meyer O, Kalus U, Pruß A, Kurth F, Zoller T, Witzenrath M, Sander LE, Müller MA, Scheibenbogen C, Volk HD, Drosten C, Corman VM, Hanitsch LG.
Frontiers in Immunology 2021, 11, 628971. DOI
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Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months.
Steinbeis F, Thibeault C, Doellinger F, Ring RM, Mittermaier M, Ruwwe-Glösenkamp C, Alius F, Knape P, Meyer HJ, Lippert LJ, Helbig ET, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Penzkofer T, Witzenrath M, Zoller T.
Respiratory Medicine 2021, 191, 106709. DOI
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COVID-19 vs. Classical Myocarditis Associated Myocardial Injury Evaluated by Cardiac Magnetic Resonance and Endomyocardial Biopsy.
Tanacli R, Doeblin P, Götze C, Zieschang V, Faragli A, Stehning C, Korosoglou G, Erley J, Weiss J, Berger A, Pröpper F, Steinbeis F, Kühne T, Seidel F, Geisel D, Walter-Rittel TC, Stawowy P, Witzenrath M, Klingel K, Van Linthout S, Pieske B, Tschöpe C, Kelle S.
Frontiers in Cardiovascular Medicine 2021, 8, 737257. DOI
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Clinical and virological characteristics of hospitalised COVID-19 patients in a German tertiary care centre during the first wave of the SARS-CoV-2 pandemic: a prospective observational study.
Thibeault C, Mühlemann B, Helbig ET, Mittermaier M, Lingscheid T, Tober-Lau P, Meyer-Arndt LA, Meiners L, Stubbemann P, Haenel SS, Bosquillon de Jarcy L, Lippert L, Pfeiffer M, Stegemann MS, Roehle R, Wiebach J, Hippenstiel S, Zoller T, Müller-Redetzky H, Uhrig A, Balzer F, von Kalle C, Suttorp N, Jones TC, Drosten C, Witzenrath M, Sander LE, Pa-COVID Study Group, Corman VM, Kurth F.
Infection 2021, 49(4), 703-714. DOI
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Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01.
Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J, Pineda JA, Fernandez-Fuertes M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Salvo M, Blueher A, Siemann S, Jurisic S, Beer JH, Rutishauser J, Wiggli B, Schmid H, Danninger K, Binder R, Corman VM, Mühlemann B, Arjun Arkal R, Fragiadakis GK, Mick E, Comet C, Calfee CS, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Langelier CR, Venkataramani U, García F, Zyla J, Drosten C, Alice B, Jones TC, Suttorp N, Witzenrath M, Hippenstiel S, Zemojtel T, Skurk C, Wolfgang P, Borodina T, Pa-Covid SG, Ripke S, Sander LE, Beule D, Landmesser U, Guettouche T, Kurth F, Heidecker B.
eClinicalMedicine 2021, 40, 101099. DOI
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SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE.
Cell 2021, 184(26), 6243-6261.e27. DOI
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The CypA-netics of Ventilator-induced Lung Injury.
Witzenrath M, Kuebler WM.
American Journal of Respiratory Critical Care Medicine 2021, 204(4), 385-387. DOI
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.
Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, Noth R, Pickkers P, Rabe KF, Renz A, Röcken C, Rupp J, Schaffarzyk A, Scheffold A, Schulte-Schrepping J, Schunk D, Skowasch D, Ulas T, Wandinger KP, Wittig M, Zimmermann J, Busch H, Hoyer BF, Kaleta C, Heyckendorf J, Kox M, Rybniker J, Schreiber S, Schultze JL, Rosenstiel P. HCA Lung Biological Network, Deutsche COVID-19 Omics Initiative (DeCOI).
Immunity 2020, 53(6), 1296-1314. DOI
The German Corona Consensus Dataset (GECCO): a standardized dataset for COVID-19 research in university medicine and beyond.
Sass J, Bartschke A, Lehne M, Essenwanger A, Rinaldi E, Rudolph S, Heitmann K, Vehreschild JJ, von Kalle, C, Thun, S.
BMC Medical Informatics and Decision Making 2020, 20, 341. DOI